lidocaine n : a local anesthetic (trade names Lidocaine and Xylocaine) used topically on the skin and mucous membranes [syn: Xylocaine]

English

Noun

1. A local anesthetic that is also used as a antiarrhythmic drug

Synonyms

• lignocaine

Lidocaine (INN) () or lignocaine (former BAN) (/ˈlɪgnoʊkeɪn/) is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, and in minor surgery. The most commonly encountered lidocaine preparations are marketed by Abraxis Pharmaceutical Products under the brand names Xylocaine and Xylocard, and as 'Lanacane' topical ointment in the UK, though lidocaine is also found in many other proprietary preparations.

History

Lidocaine, the first amino amide-type local anesthetic, was first synthesized under the name xylocaine by Nils Löfgren in 1943. His colleague Bengt Lundqvist made the first injection anesthesia experiments on himself.. With sufficient blockade, the membrane of the presynaptic neuron will not depolarize and so fail to transmit an action potential, leading to its anesthetic effects. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.

Clinical use

Indications

Indications for the use of lidocaine include:

• Topical, infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia, IV regional anaesthesia (IVRA)
• Treatment of serious ventricular arrhythmias (IV preparations), including ventricular fibrillation (VF) and ventricular tachycardia (VT) associated with cardiac arrest

Topical lidocaine has been shown to relieve postherpetic neuralgia in some patients, although there is not enough study evidence to recommend it as a first-line treatment. (Khaliq et al., 2007)

Intravenous/Intraosseous Used to blunt effects of laryngoscopy during rapid sequence intubation procedures, especially in cases of head injury.

Contraindications

Contraindications for the use of lidocaine include:

• Heart block, second or third degree (without pacemaker)
• Severe sinoatrial block (without pacemaker)
• Serious adverse drug reaction to lidocaine or amide local anaesthetics
• Concurrent treatment with quinidine, flecainide, disopyramide, procainamide (Class I antiarrhythmic agents)
• Prior use of Amiodarone Hydrochloride
• Hypotension not due to Arrhythmia
• Bradycardia
• Accelerated idioventricular rhythm

Adverse drug reactions

Adverse drug reactions (ADRs) are rare when lidocaine is used as a local anesthetic and is administered correctly. Most ADRs associated with lidocaine for anesthesia relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, but allergic reactions can rarely occur..

Systemic exposure to excessive quantities of lidocaine mainly result in central nervous system (CNS) and cardiovascular effects – CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures) followed by depression, and with increasingly heavier exposure: drowsiness, loss of consciousness, respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest – some of which may be due to hypoxemia secondary to respiratory depression. (Rossi, 2006)

ADRs associated with the use of intravenous lidocaine are similar to toxic effects from systemic exposure above. These are dose-related and more frequent at high infusion rates (≥3 mg/minute). Common ADRs include: headache, dizziness, drowsiness, confusion, visual disturbances, tinnitus, tremor, and/or paraesthesia. Infrequent ADRs associated with the use of lidocaine include: hypotension, bradycardia, arrhythmias, cardiac arrest, muscle twitching, seizures, coma, and/or respiratory depression. (Rossi, 2006)

Insensitivity to lidocaine

Relative insensitivity to lidocaine runs in families. In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder. In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves.

Dosage forms

Lidocaine, usually in the form of lidocaine hydrochloride, is available in various forms including:

• Injected local anesthetic (sometimes combined with epinephrine)
• Dermal patch (sometimes combined with prilocaine)
• Intravenous injection (sometimes combined with epinephrine)
• Intravenous infusion
• Nasal instillation/spray (combined with phenylephrine)
• Oral gel (often referred to as "viscous lidocaine" or abbreviated "lidocaine visc" or "lidocaine hcl visc" in pharmacology; used as teething gel)
• Oral liquid
• Topical gel (as with Aloe Vera gels that include Lidocaine)
• Topical liquid
• Topical patch (Lidocaine 5% patch is marketed as "Lidoderm" in the US (since 1999) and "Versatis" in the UK (since 2007 by Grünenthal))

Additive in cocaine

Lidocaine is often added to cocaine as a diluent. Cocaine numbs the gums when applied, and since lidocaine causes stronger gingival numbness, customers get the impression of high-quality cocaine when in actuality, the user is receiving a diluted product.

References

• ">http://www.cochrane.org/reviews/en/ab004846.html}}
• Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3

Cinematic References

• In the film No Country for Old Men, Anton Chigurh uses Lidocaine when repairing the gun shot wound in his upper left leg.
• In Casino Royale, James Bond (Daniel Craig) is advised by MI6 doctors to self-inject Lidocaine after being poisoned with Digitalis.
• In the "Wandering Bear" episode of Curb Your Enthusiasm, Larry uses an "everlast" condom with lidocaine inside out, causing his wife's organs to become numb.